the most unknown inomilies in medical hiistory

Though opacity is the most characteristic sign, Peters anomaly is usually associated with other eye defects such as glaucoma (increased eye pressure that can damage the optic nerve), nystagmus (involuntary movement of the eyes), cataracts (loss of lens transparency) and retinal detachment. A loss of transparency in the central part is translated into declining vision, which is more significant the larger and denser the leukoma is. The periphery is generally respected and is characterised by a sticky substance ( synechia) between the corneal defect and the iris. The Descemet's membrane, stroma and endothelium of the central cornea are unable to develop, which leads to opacity of the central part of the cornea ( leukoma). The majority of cases are sporadic, but autosomal dominant and autosomal recessive inheritance patterns have been described, in which there is more than one family member with the same issue. Its exact cause is unknown, although genes that affect the embryonic development of the eye are found among the etiopathogenic factors. It may affect one or both eyes, although it is bilateral and asymmetric in 80% of cases. It is an uncommon condition that affects approximately 1 in every million people and is the cause of 40% of congenital corneal opacities. Peters anomaly is a congenital defect in the embryonic development of the anterior segment of the eyeball whereby patients are born with central corneal opacity. It has 5 layers: the epithelium, Bowman's membrane, the stroma, Descemet's membrane and the endothelium. In normal conditions it's a clear tissue because of its lack of blood vessels and distribution of the fibres that form it. The cornea is situated in the front part of the eyeball.

The most unknown inomilies in medical hiistory